Pure Graviola
Alternative Cancer Treatment
from Raintree Nutrition

Suggested Retail Price: $18.95
Graviola Special Price: $16.95

Graviola Cancer Treatment
The Graviola Tree - Information, Actions and Properties
Graviola Research
Graviola Suggested Use
Graviola Contraindications
Graviola Drug Interactions
Other Practitioner Observations about Graviola

Graviola Cancer Treatment & Prevention
100% Pure Graviola Extract
Unconditionally Guaranteed

Graviola, the powerful herb from the Amazon Rainforest, is helping millions of people fight through their cancer treatment. Graviola extract has been shown to have an effect on the actual cancer cells, which can be of great benefit to someone who is fighting cancer. See research on Graviola at PubMed!

Raintree's Graviola comes as 600 milligrams per capsule of pure Graviola ground leaf and stem, rich in active and beneficial phytochemicals which occur naturally in this plant. There are no binders or fillers, so the capsules are 100% finely milled Graviola powder.

Read more about Graviola at the
Complete World of Alternative Cancer Therapy
Graviola - see chapter 2, paragraph 2
Flaxseed Oil & cottage cheese, Wobenzym - see chapter 8, paragraphs 1 & 4

The Graviola Tree - Information, Actions and Properties

The Graviola is a small, upright evergreen tree growing 5 to 6 meters in height with large dark green and glossy leaves. Graviola is indigenous to most of the warmest tropical areas in South and North America including the Amazon. It produces a large heart-shaped edible fruit that is 6-9", yellow green in color, with white flesh. The fruit is sold in local markets in the tropics where it is called Guanabana or Brazilian Cherimoya and is excellent for making drinks and sherbets and, though slightly sour-acid, can be eaten out-of-hand.

Family: Annonaceae
Genus: Annona
Species: muricata
Synonyms: Annona macrocarpa, A. bonplandiana, A. cearensis, Guanabanus muricatus
Common names: Graviola, soursop, Brazilian paw paw, guanábana, guanábano, guanavana, guanaba, corossol épineux, huanaba, toge-banreisi, durian benggala, nangka blanda, cachiman épineux
Part Used: Leaves, fruit, seeds, bark, roots

Access the entire Raintree Nutrition Graviola Plant Database Here  

Graviola Research

Some of the active ingredients documented, researched, and verified in Graviola are a group of Annonaceous Acetogenins which are only found in the Annonaceae family to which Graviola belongs. These phytochemicals are being researched around the world for their active biological properties and potential uses.† An in depth Technical Data Report is available on Graviola.

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Many bioactive compounds and phytochemicals have been found in Graviola, as scientists have been studying its properties since the 1940s. Its many uses in natural medicine have been validated by scientific research. Several studies by different researchers demonstrated that the bark as well as the leaves had hypotensive, antispasmodic, anticonvulsant, vasodilator, smooth-muscle relaxant, and cardiodepressant activities in animals. Researchers verified Graviola leaf's hypotensive properties in rats again in 1991. Several studies over the years have demonstrated that leaf, bark, root, stem, and seed extracts of Graviola are antibacterial in vitro against numerous pathogens, and that the bark has anti-fungal properties. Graviola seeds demonstrated active anti-parasitic properties in a 1991 study, and a leaf extract showed to be active against malaria in two other studies (in 1990 and 1993). The leaves, root, and seeds of Graviola demonstrated insecticide properties, with the seeds demonstrating strong insecticidal activity in an early 1940 study. In a 1997 clinical study, novel alkaloids found in Graviola fruit exhibited anti-depressive effects in animals. 

One researcher summarized his work eloquently: "At the time of preparation (August 1998) of this current review, over 350 Annonaceous acetogenins have been isolated from 37 species. Our preliminary efforts show that about 50%, of over 80 Annonaceous species screened, are significantly bioactive and are worthy of fractionation; thus, this class of compounds can be expected to continue to grow at an exponential rate in the future, provided that financial support for such research efforts can be found. With the demise of the world's tropical rain forests, such work is compelling before the great chemical diversity, contained within these endangered species, is lost." Perhaps--if enough people believe that cancer treatment is truly locked away in a rainforest plant--we will take the steps needed to protect our remaining rainforests from destruction.

Annonaceous acetogenins are only found in the Annonaceae family (to which Graviola belongs). In general, various Annonaceous acetogenins in the plant family have been documented with antitumorous, antiparasitic, pesticidal, antiprotozoal, antifeedant, anthelmintic, and antimicrobial activities. Mode of action studies in three separate laboratories have recently determined that these acetogenins are superb inhibitors of enzyme processes that are only found in the membranes of cancerous tumor cells. Purdue University, in West Lafayette, Indiana, has conducted a great deal of the research on the acetogenins, much of which has been funded by The National Cancer Institute and/or the National Institute of Health (NIH). Thus far, Purdue University and/or its staff have filed at least nine U.S. and/or international patents on their work around the antitumorous and insecticidal properties and uses of these acetogenins. In one of their reviews, titled "Recent Advances in Annonaceous Acetogenins," they state, "Recently, we reported that the Annonaceous acetogenins can selectively inhibit the growth of cancerous cells and also inhibit the growth of adriamycin resistant tumor cells. As more acetogenins have been isolated and additional cytotoxicity assays have been conducted, we have noticed that, although most of acetogenins have high potencies among several solid human tumor cell lines, some of the derivatives within the different structural types and some positional isomers showed remarkable selectivities among certain cell lines; e.g., against prostate cancer (PC-3). We now understand the primary modes of action for the acetogenins. They are potent inhibitors of NADH: ubiquinone oxidoreductase, which is in an essential enzyme in complex I leading to oxidative phosphorylation in mitochondria. A recent report showed that they act directly at the ubiquinone-catalytic site(s) within complex I and in microbial glucose dehydrogenase. They also inhibit the ubiquinone-linked NADH oxidase that is peculiar to the plasma membranes of cancerous cells."

Graviola Suggested Use:
2- 4 capsules, three times daily, between meals.


Graviola Contraindications: 

- Not to be used during pregnancy or breast-feeding. 

- Graviola is contraindicated in combination with CoQ10 and other supplements which increase cellular ATP. One mechanism of action of Graviola is as an ATP-inhibitor. 

- Graviola has demonstrated hypotensive, vasodilator, and cardiodepressant activities in animal studies. People with low blood pressure or taking antihypertensive drugs should check with their doctors before taking Graviola and monitor their blood pressure accordingly. 

- One study with rats given a stem-bark extract intragastrically (at 100 mg/kg) reported an increase in dopamine, norepinephrine, and monomine oxidase activity, as well as a inhibition of serotonin release in stress-induced rats. As such, the use of this plant is probably contraindicated in combination with MAO inhibitors and some prescription antidepressants. Check with your doctor first if you are taking prescription antidepressants or MAO inhibitor drugs prior to taking Graviola.


Graviola Drug Interactions:

None have been reported; however: 

Graviola may potentiate antihypertensive and cardiac depressant drugs. It may potentiate antidepressant drugs and interfere with MAO-inhibitor drugs. See contraindications above.  CoQ10 and other drugs and supplements which increase ATP may reduce the effects of Graviola.


Other Practitioner Observations about Graviola: 

Graviola has demonstrated significant in vitro antimicrobial properties. Chronic, long-term use of this plant may lead to die-off of friendly bacteria in the digestive tract due to its antimicrobial properties. Supplementing the diet with probiotics and digestive enzymes is advisable if this product is used for longer than 30 days. 

Graviola has demonstrated emetic properties in one animal study with pigs. Large single dosages may cause nausea or vomiting. Reduce the usage accordingly or take with a meal if nausea occurs. 

Drinking plenty of water (at least 8 glasses a day) is helpful to reduce Herxheimer reactions.  This plant has been used indigenously as a sedative (in large amounts). Reduce usage if sedation occurs.