Special Advertised Price: $19.95
While Supplies Last

Graviola-Max New Advanced Alternative Cancer Therapy
NEW COMBINED SPECIES GRAVIOLA EXTRACT
UNCONDITIONALLY GUARANTEED!

Annonaceous acetogenins are only found in the Annonaceae plant family. Graviola (Annona muricata) Some of the active ingredients documented, researched, and verified in graviola are a group. The Annonacece plant family has 82 different acetogenin chemicals in 10 distinct types. Mountain graviola, or Annona montana, contains the main annonacin chemical that graviola contains, and it has 26 more acetogenin chemicals (in 6 distinct types) not found in regular graviola!

Graviola-Max provides 12 different types of acetogenins by combining both species of graviola (Annona muricata and Annona montana) with 108 distinct powerful chemicals in all. American paw paw has only 28 acetogenin chemicals! Graviola-Max delivers almost four times more acetogenins than paw paw! This chart compares the acteogenin chemicals in all three plants.

There is also a complete file available on Graviola-Max at Raintree's database of plant information . These graviola plants are sustainably harvested in the Amazon Rainforest. This Raintree product contains no fillers, binders or exipients and is 100 percent natural finely milled plant. This product is backed by Raintree's Unconditional Guarantee.

Print PDF Documents:
Graviola-Max Brochure

Some of the active ingredients documented, researched, and verified in Graviola are a group of Annonaceous Acetogenins which are only found in the Annonaceae family to which Graviola belongs. These phytochemicals are being researched around the world for their active biological properties and potential uses. An in depth Technical Data Report is available on Graviola.

If you do not have Adobe Acrobat reader to access these pdf files:

click on this image to download the reader.

Read more about Graviola at the
Complete World of Alternative Cancer Therapy
(Graviola - see chapter 2, paragraph 2)

Purchase Graviola-Max Now
A 120 capsule bottle

Ingredients:
A proprietary blend of graviola leaf and stem (Annona muricata), and mountain graviola leaf and stem (Annona montana).

Suggested Use:
Take 3 capsules 3-4 times or as directed by a healthcare professional.

Contraindications:
Not to be used during pregnancy or breast-feeding.
Graviola has demonstrated hypotensive, vasodilator, and cardiodepressant activities in animal studies. People with low blood pressure should monitor their blood pressure accordingly.

Drug Interactions:
None have been reported; however, based on animal studies, graviola may potentiate antihypertensive and cardiac depressant drugs.

Other Observations:
Graviola has demonstrated in vitro antimicrobial properties. Chronic, long-term use of this plant might lead to some die-off of friendly bacteria in the digestive tract. Supplementing the diet with probiotics and digestive enzymes may be helpful to counteract this possible effect.
Graviola has demonstrated emetic properties in one animal study with pigs. Large single dosages may cause nausea or vomiting. Reduce the usage accordingly or take with a meal if nausea occurs. Drinking plenty of water (at least 8 glasses a day) is helpful to reduce Herxheimer reactions and flush dead and dying cells from the body. One of three documented mechanisms of action of graviola is by decreasing energy to abnormal cells (called an ATP-inhibitor). Taking supplements that increase cellular energy (like CoQ10) will counteract or disable this one mechanism of action of graviola (however, the other two mechanisms of action will be unaffected).

Third-Party Published Research*

All available third-party research on these graviola plants can be found at PubMed/Medline. This Raintree product has not been the subject of any clinical research. A partial listing of the published research on these graviola plants are shown below:

Graviola (Annona muricata) Takahashi, J. A., et al. "Antibacterial activity of eight Brazilian Annonaceae plants." Nat. Prod. Res. 2006; 20(1): 21-6. Kojima, N. "Systematic synthesis of antitumor Annonaceous acetogenins" Yakugaku Zasshi. 2004; 124(10): 673-81 Yuan, S. S., et al. "Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway." Life Sci. 2003 May: 72(25): 2853-61. Liaw, C. C., et al. "New cytotoxic monotetrahydrofuran Annonaceous acetogenins from Annona muricata." J. Nat. Prod. 2002; 65(4): 470-75. Gonzalez-Coloma, A., et al. "Selective action of acetogenin mitochondrial complex I inhibitors." Z. Naturforsch. 2002; 57(11-12): 1028-34. Chang, F. R., et al. "Novel cytotoxic Annonaceous acetogenins from Annona muricata." J. Nat. Prod. 2001; 64(7): 925-31. Padma, P., et al. "Effect of Annona muricata and Polyalthia cerasoides on brain neurotransmitters and enzyme monoamine oxidase following cold immobilization stress." J. Natural Remedies 2001; 1(2): 144-46. Jaramillo, M. C., et al. "Cytotoxicity and antileishmanial activity of Annona muricata pericarp." Fitoterapia. 2000; 71 (2): 183-6. Betancur-Galvis, L., et al. "Antitumor and antiviral activity of Colombian medicinal plant extracts." Mem. Inst. Oswaldo Cruz. 1999; 94(4): 531-35. Kim, G. S., et al. "Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata." Phytochemistry. 1998; 49(2): 565-71. Kim, G. S., et al. "Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata." J. Nat. Prod. 1998; 61(4): 432-36. Nicolas, H., et al. "Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells." J. Med. Chem. 1997; 40(13): 2102-6. Zeng, L., et al. "Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata." J. Nat. Prod. 1996; 59(11): 1035-42. Wu, F. E., et al. "Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata." J. Nat. Prod. 1995; 58(6): 830-36. Wu, F. E., et al. "Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata." J. Nat. Prod. 1995; 58(9): 1430-37. Wu, F. E., et al. "New bioactive monotetrahydrofuran Annonaceous acetogenins, annomuricin C and muricatocin C, from the leaves of Annona muricata." J. Nat. Prod. 1995; 58(6): 909-5. Wu, F. E., et al. "Muricatocins A and B, two new bioactive monotetrahydrofuran Annonaceous acetogenins from the leaves of Annona muricata." J. Nat. Prod. 1995; 58(6): 902-8. Sundarrao, K., et al. "Preliminary screening of antibacterial and antitumor activities of Papua New Guinean native medicinal plants." Int. J. Pharmacog. 1993; 31(1): 3-6. Heinrich, M., et al. "Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico)." J. Ethnopharmacol. 1992; 36(1): 81-5. Mountain Graviola (Annona montana) Liaw, C. C., et al. "Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana." Bioorg. Med. Chem. 2005 Aug; 13(15): 4767-76. Tormo, J. R., et al. "In vitro antitumor structure-activity relationships of threo/trans/threo/trans/erythro bis-tetrahydrofuranic acetogenins: correlations with their inhibition of mitochondrial complex I." Oncol. Res. 2005; 15(3): 129-38. Liaw, C. C., et al. "Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran Annonaceous acetogenins from Annona montana." J. Nat. Prod. 2004; 67(11): 1804-8. Liaw, C. C., et al. "Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana." Planta Med. 2004; 70(10): 948-59. Kojima, N. "Systematic synthesis of antitumor annonaceous acetogenins." Yakugaku Zasshi. 2004; 124(10): 673-81 Wang, L. Q., et al. "Annonaceous acetogenins from the leaves of Annona montana." Bioorg. Med. Chem. 2002; 10(3): 561-5. Wang, L. Q., et al. "Cytotoxic mono-tetrahydrofuran ring acetogenins from leaves of Annona montana." Planta Med. 2001 Dec; 67(9): 847-52. Mootoo, B. S., et al. "Three novel monotetrahydrofuran annonaceous acetogenins from Annona montana."J. Nat. Prod. 2000; 63(6): 807-11. Yang, S., et al. "Chemical constituents of Annonaceae plants and their antitumor activities." Zhongguo Yi. Xue. Ke. Xue. Yuan. Xue. Bao. 2000 Aug; 22(4): 376-82. Wang, L. Q., et al. "Four mono-tetrahydrofuran ring acetogenins, montanacins B-E, from Annona montana." Chem. Pharm. Bull. 2000; 48(8): 1109-13. Wu, Y. C., et al. "Bioactive constitutents from the stems of Annona montana." Planta Med. 1995 Apr; 61(2): 146-9. Jossang, A., et al. "Annomonysvin: a new cytotoxic gamma-lactone-monotetrahydrofuranyl acetogenin from Annona montana." J. Nat. Prod. 1991 Jul-Aug; 54(4): 967-71.