N-TENSE 2 combines another combination of the most powerful medicial plants of the rainforest into a second potent formula shown to actively fight human cancer cells. The plants in this formula have been independently documented around the world with active pharmacological actions. For an overview of the clinical documentation on these plants please click here to read the NTense-2 Product Brochure.
Each rainforest botanical in N-TENSE has been sustainably wild-harvested in the Amazon Rainforest. Raintree Nutrition GUARANTEES their products are processed without chemicals or irradiation and the capsules contain no binders, fillers, or exipients and are 100% finely milled natural plants.
This high quality formula is sold in 120 capsule bottles with 700 milligrams per capsule. It is backed by Raintree's Unconditional Guarantee.
Below is only a partial list of the published research on each pure herb ingredient in the N-Tense 2 formula.
Mullaca (Physalis angulata)
Chiang, H. et al. “Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro.” Anticancer Res. 1992; 12(4): 1155–62.
Chiang, H., et al. “Antitumor agent, physalin F from Physalis angulata L.” Anticancer Res. 1992; 12(3): 837–43.
Ismail, N., et al. “A novel cytotoxic flavonoid glycoside from Physalis angulata.” Fitoterapia 2001 Aug. 72(6): 676–79.
Kawai, M., et al. “Cytotoxic activity of physalins and related compounds against HeLa cells.” Pharmazie. 2002; 57(5): 348–50.
Anamu (Petiveria alliacea)
Mata-Greenwood, E., et al. "Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells." Anticancer Res. 2001; 21(3B): 1763-70.
Rossi, V., et al. "Antiproliferative effects of Petiveria alliacea on several tumor cell lines." Pharmacol. Res. Suppl. 1990; 22(2): 434.
Jovicevic, L., et al. "In vitro antiproliferative activity of Petiveria alliacea L. on several tumor cell lines." Pharmacol. Res. 1993; 27(1): 105-06.
Quadros, M. R., et al., "Petiveria alliacea L. extract protects mice against Listeria monocytogenes infection-effects on bone marrow progenitor cells." Immunopharmacol. Immunotoxicol. 1999 Feb; 21(1): 109-24.
Williams, L., et al. "Immunomodulatory activities of Petiveria alliaceae L." Phytother. Res. 1997; 11(3): 251-253.
Vassourinha (Scoparia dulcis)
Noda, Y., et al. “Enhanced cytotoxicity of some triterpenes toward leukemia L1210 cells cultured in low pH media; possibility of a new mode of cell killing.” Chem. Pharm. Bull. 1997; 45(10): 1665–70.
Nishino, H. “Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L.” Oncology 1993; 50(2): 100–3.
Hayashi, T., et al. “A cytotoxic flavone from Scoparia dulcis L.” Chem. Pharm. Bull. (Tokyo). 1988; 36(12): 4849-51.
Ahsan, M., et al. “Cytotoxic diterpenes from Scoparia dulcis.” J. Nat. Prod. 2003; 66(7): 958-61.
Simarouba (Simarouba amara)
Klocke, J. A., et al. “Growth inhibitory, insecticidal and antifeedant effects of some antileukemic and cytotoxic quassinoids on two species of agricultural pests.” Experientia. 1985 Mar 15; 41(3): 379-82.
Liou, Y. F., et al. “Antitumor agents XLVIII: Structure-activity relationships of quassinoids as in vitro protein synthesis inhibitors of P-388 lymphocytic leukemia tumor cell metabolism.” J. Pharm. Sci. 1982 Apr; 71(4): 430-5.
Mata-Greenwood, E., et al. “Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture.” J. Nat. Prod. 2001 Dec;64(12):1509-13.
Valeriote, F. A., “Anticancer activity of glaucarubinone analogues.” Oncol. Res. 1998; 10(4):201-8.
Picão Preto (Bidens pilosa)
Chang, J.S., et al. "Antileukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb." Am. J. Chin. Med. 2001;29(2):303-12.
Wang, J., et al. "Inhibition of 5 compounds from Bidens bipinnata on leukemia cells in vitro." Zhong Yao Cai. 1997 May;20(5):247-9.
Wu, L. W., et al. "Polyacetylenes function as anti-angiogenic agents." Pharm Res. 2004 Nov;21(11):2112-9.
Chiang, Y. M., et al. "Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa." J Ethnopharmacol. 2004 Dec;95(2-3):409-19.
Suma (Pfaffia paniculata)
Watanabe, T., et al. “Effects of oral administration of Pfaffia paniculata (Brazilian ginseng) on incidence of spontaneous leukemia in AKR/ J mice.” Cancer Detect. Prev. 2000; 24(2): 173–8.
Nakai, S., et al. “Pfaffosides. Part 2. Pfaffosides, nortriterpenoid saponins from Pfaffia paniculata.” Phytochemistry 1984; 23(8): 1703–05.
Takemoto, T., et al. Antitumor pfaffosides from Brazilian carrots. Japanese patent no. 84/ 184,198. October 19, 1984
Cat’s Claw (Uncaria tomentosa)Available Separately
Stuppner, H. et al., "A differential sensitivity of oxindole alkaloids to normal and leukemic cell lines." Planta Med. 1993; 59 suppl: A583.
Winkler, C., et al. "In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cells." Planta Med. 2004 Mar;70(3):205-10.
Sheng, Y. "Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.” Phytomedicine. 2000 Apr;7(2):137-43.
Sheng, Y. "Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa.” Anticancer Res. 1998 Sep-Oct;18(5A): 3363-8.
Sheng Y, et al., "DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study." Phytomedicine 2001; 8(4): 275-82.
Espinheira Santa (Maytenus ilicifolia)
Ohsaki, A., et al. "Four new triterpenoids from Maytenus ilicifolia." J Nat Prod. 2004 Mar;67(3):469-71.
Nakao, H., et al. "Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562 cells." Biol Pharm Bull. 2004 Aug;27(8):1236-40.
Shirota, O., et al. "Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus chuchuhuasca." J. Nat. Prod. 1994; 57(12): 1675-81.
Itokawa, H., et al. "Oligo-nicotinated sesquiterpene polyesters from Maytenus ilicifolia." J. Nat. Prod. 1993; 56(9); 1479-1485.
Itokawa, H., et al. "Cangorins F-J, five additional oligo-nicotinated sesquiterpene polyesters from Maytenus ilicifolia." J. Nat. Prod. 1994; 57(4): 460-70.
Buffa Filho, W., et al. "Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid chromatography." Phytochem Anal. 2002 Mar-Apr;13(2):75-8
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